Saxenda (liraglutide)

Saxenda (liraglutide)

£499.00

Saxenda (liraglutide) is a once-daily weight loss injectable medication that helps individuals achieve sustainable weight loss. It works by reducing appetite, which increases feelings of fullness and helps you consume fewer calories.

✔ Targets appetite regulation
✔ Backed by clinical trials
✔ Helps you feel fuller for longer
✔ Simple once-daily injection using a pre-filled pen
✔ Assessed and approved by our expert pharmacy team
✔ Discreet delivery across the UK

Once you complete your health assessment, our clinicians will review your information to ensure Saxenda is suitable for you. If approved, we’ll deliver it in secure packaging with ongoing support from our private weight management service at Star Pharmacy.

What is Saxenda?

Saxenda (liraglutide) is a once-daily injectable medication designed to support weight management in individuals with obesity or those who are overweight with weight-related health concerns. It works by reducing appetite and increasing feelings of fullness, helping you eat less and lose weight more effectively. It is a part of a class of medications known as GLP-1 receptor agonists, which help regulate appetite and energy intake. Unlike standard weight loss methods, Saxenda works by addressing the factors that contribute to overeating and weight gain, making it an effective option for those who have found diet and exercise alone to be insufficient.

How does Saxenda work?

Saxenda contains Liraglutide, which mimics the body’s natural appetite-controlling hormone. It works by:
  • Reducing appetite 
  • Saxenda acts on areas of the brain that regulate hunger, helping to suppress cravings and reduce the urge to eat between meals.
  • Slows digestion
  • It slows down the rate at which food leaves your stomach, which helps keep you feeling full for longer after eating.
  • Feelings of fullness
  • Saxenda enhances the body’s natural signals of fullness, so you are more likely to stop eating when satisfied.Together, these effects help you eat fewer calories, stay satisfied longer, and build healthier eating habits over time. Saxenda helps patients lose 5-10% body weight when combined with a reduced-calorie diet and physical activity.

    How effective is Saxenda for weight loss?

    Clinical SCALE trials demonstrate that, over 56 weeks, Saxenda achieves an average 8% weight loss versus 2.6% for placebo. Most patients experience measurable reductions within 12 weeks, and ongoing use helps maintain results when combined with lifestyle changes. Saxenda has been extensively studied in the SCALE clinical trial program. Results consistently showed that:
    • Average weight loss was 8% of initial body weight after 56 weeks when used alongside a reduced-calorie diet and regular exercise.
    • This compares to just 2.6% weight loss with placebo under the same lifestyle conditions.
    • Many participants lost 5–10% or more of their initial weight.
    • Improvements were also seen in blood sugar control, blood pressure, and cholesterol levels.
    Most users begin to see noticeable weight loss within 12 weeks of starting Saxenda. For those who respond well, ongoing use helps maintain and build on early results, especially when paired with continued lifestyle changes.
 

Saxenda is licensed for adults who meet all of the following:

  • Aged 18 or over
  • Body mass index (BMI) of 30 kg/m² or above (obesity)
  • BMI 28 kg/m² or above (overweight) with at least one weight‑related condition, such as:
    • Type 2 diabetes
    • High blood pressure
    • High cholesterol
    • Obstructive sleep apnoea
  • Not pregnant or breastfeeding
  • Not taking any other GLP‑1 receptor agonists

It is not a substitute for healthy eating and physical activity, but is most effective when used in combination with both.

Contraindications

  • Thyroid cancer risk:

Not for use in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

  • Hypersensitivity:

Individuals with a known allergy to liraglutide or any component of Saxenda. Anaphylaxis and angioedema cases have been reported; discontinue immediately if symptoms arise.

Major safety risks & monitoring

  • Risk of thyroid C‑cell tumours

Patients should be educated about symptoms such as neck lumps, difficulty swallowing, hoarseness, or breathing changes. Serum calcitonin testing or ultrasound scans are of unclear benefit for early detection.

  • Acute pancreatitis

Discontinue if patients experience persistent, severe abdominal pain (possibly radiating to the back), particularly with vomiting.

  • Acute gallbladder disease

Rapid weight loss with Saxenda use increases the risk of gallstones and cholecystitis even after adjusting for weight change.

  • Hypoglycaemia risk

When used with insulin, the risk of low blood sugar increases. Monitor for symptoms and consider medication dose adjustment in consultation with a healthcare provider.

  • Increased heart rate

Many patients may experience a rise in resting heart rate. Persistent symptoms such as palpitations need clinical evaluation.

  • Renal effects

Severe nausea, vomiting, or diarrhoea may lead to dehydration and acute kidney injury, even requiring dialysis in rare cases.

  • Severe gastrointestinal reactions

Persistent or worsening nausea, vomiting, diarrhoea, or constipation should prompt clinical review. These GI symptoms affect many patients and require close monitoring

  • Hypersensitivity reactions

Serious allergic responses, including rash, itching, angioedema, or anaphylaxis, have been observed. Stop Saxenda immediately and seek medical advice if these occur.

  • Mental conditions 

Individuals with pre-existing mental health conditions or depression history should be monitored closely.

  • Medicine interactions 

  • Saxenda and insulin should not be used simultaneously.

    Patient Counseling

    Patients should be made aware that Saxenda, while effective for weight management, is not suitable for everyone and carries specific risks requiring medical oversight. Prompt reporting of relevant symptoms and maintaining regular checks ensure safer use and better outcomes.

  • Dosage and Administration

    • Usage frequency

    Inject once daily, at roughly the same time each day

    • Starting Dose

    0.6 mg for 1 week

    • Titration

    Increase by 0.6 mg each week until reaching 3.0 mg daily (maintenance dose)

    • Maximum Dose

    3.0 mg per day

    Injection Technique

    • Sites: Abdomen, front of thigh or back of upper arm
    • Rotation: Change the injection site daily to minimise skin irritation
    • Needle Angle: Insert at 45–90° depending on subcutaneous tissue thickness
    • Missed Dose:
      • If under 12 hours late: administer as soon as you remember
      • If over 12 hours late: skip and resume your regular schedule, do not double up

    Storage and Disposal

    • Storage: Keep pens refrigerated at 2–8 °C (36–46 °F); do not freeze
    • Preparation: Before injection, allow the pen to stand at room temperature for 30 minutes
    • Shelf‑Life: Use each pen within 30 days of first use
    • Disposal: After use, place the pen in a designated sharps container. It is also advised not to reuse or share your pen with anyone.

    Always follow the instructions provided during your consultation and on the packaging of the weight loss medication.

    Ready to start your weight loss journey? Buy Saxenda Online UK at Star Pharmacy.

    Active ingredient

    The active ingredient in Saxenda is Liraglutide

    A long‑acting GLP‑1 receptor agonist that:

    • Mimics the body’s naturally occurring hunger hormone
    • Enhances glucose‑dependent insulin secretion
    • Slows gastric emptying to prolong fullness

    Inactive ingredients

    • Disodium phosphate dihydrate

    Buffers the solution and maintains pH stability, protecting peptide integrity.

    • Phenol

    Acts as a preservative to prevent microbial growth in the multi-use pen.

    • Propylene glycol

    Serves as a stabiliser, ensuring uniform drug distribution.

    • Water for injection

    Provides a sterile, pyrogen‑free medium for all ingredients.

    • Hydrochloric acid or sodium hydroxide

    Adjusts pH, optimising its solubility and comfort

    Each prefilled pen delivers precise doses, preserving drug stability through specialised packaging and temperature control.

    Common side effects 

    • Diarrhoea
    • Frequent, loose or watery stools. This often occurs in the first few weeks as your body adjusts.
      • Vomiting

      Forceful expulsion of stomach contents, usually related to nausea.

      • Constipation

      Infrequent, hard or difficult stools.

      • Stomach pain

      Cramping or discomfort in the abdominal area.

      • Headache

      Mild to moderate pain or pressure in the head.

      • Indigestion (dyspepsia)

      Burning sensation or discomfort in the upper abdomen or chest after eating.

      Less common side effects 

      • Gallstones

      Report persistent or severe abdominal pain to your doctor. An ultrasound may be required for diagnosis.

      • Pancreatitis

      Inflammation of the pancreas, presenting as sudden, severe abdominal pain that may radiate to the back, often accompanied by nausea and vomiting. Seek urgent medical care.

      • Allergic reactions

      Symptoms can include rash, itching, hives, swelling of the lips or face, or difficulty breathing. Discontinue Saxenda immediately and seek medical help if you notice signs of an allergic reaction. Anaphylaxis (severe breathing difficulty, rapid heartbeat) requires emergency treatment.

      Report any serious side effects to our pharmacist and seek medical help immediately.

      Management Strategies 

      • Sip clear fluids to prevent dehydration.
      • Eat binding foods such as bananas, rice and toast or consider a mild over‑the‑counter antidiarrhoeal if approved by your doctor.
      • For constipation, increase dietary fibre (whole grains, vegetables, fruits) and fluid intake. Gentle exercise (e.g. walking) can stimulate bowel movements.
      • Eat small, bland meals and avoid rich or spicy foods to prevent stomach pain.

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    FAQs

    How to use weight loss injections?

    They’re usually taken once a week using a simple pre-filled pen. You inject it yourself, following the step-by-step guidance from our healthcare provider.

    Yes, when prescribed and monitored by our professionals at Star Pharmacy. Some people may experience temporary side effects like nausea, headaches, or mild digestive changes.

    Each pen contains four doses, so it will last for around one month when used weekly.

    Generally for adults with a BMI of 30+, or 27+ if you have weight-related conditions like diabetes or high blood pressure. Your eligibility will be confirmed in a consultation.

    Possible side effects include nausea, vomiting, diarrhoea, constipation, and mild headaches. These effects are usually temporary and improve as your body adjusts to the medication.

    Use the formula: weight (kg) ÷ height (m²), or check with any online BMI calculator for quick results.

    Prescription based weight loss injections called a GLP-1 injection help you reduce appetite and help control hunger, making it easier to lose weight and keep it off.

    Saxenda is a once-weekly injectable prescription weight loss medication which mimics the hormone GLP-1 to regulate appetite. It helps reduce hunger, increase feelings of fullness, and lower overall calorie intake, leading to sustainable weight loss.

    Saxenda is recommended for adults aged 18–74 with a BMI of 30 or above, or 27+ with a weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol.

    Saxenda is injected once daily subcutaneously in the stomach, thigh, or upper arm. It’s taken at the same time each day, with the dose gradually increased over five weeks to the maintenance dose of 3.0 mg.

    Yes, Saxenda is a prescription-only medicine in the UK. You will need a consultation with one of our qualified professionals to assess your suitability for it.

    The most common side effects include nausea, diarrhoea, constipation, or vomiting. Headaches, tiredness, and indigestion may also occur in some users.

    Clinical studies show that patients using Saxenda alongside a healthy diet and exercise can lose 5–10% of their body weight.

    Saxenda is available on the NHS in limited cases, typically through specialist weight management services or hospital programmes. Mostly, individuals get it privately.

    While using Saxenda, avoid overeating, alcohol and combining it with other weight loss medications. This helps in worsening the side effects associated with the weight loss injection.

    If you stop Saxenda, your appetite may return to normal levels, which could lead to weight regain over time.